![]() We further found that the cytoplasmic tyrosine kinase, Abl, is required for dysregulated Dscam to promote presynaptic terminal growth and that Abl inhibitors attenuates the neurological defects caused by Dscam overexpression (Sterne et al., 2015). ![]() DSCAM levels in the brain are changed in Down syndrome and several other brain disorders. The gene encoding the human homolog of Dscam (called DSCAM) is on chromosome 21, which is present as three copies in Down syndrome individuals. We discovered that the expression level of Down syndrome cell adhesion molecule (Dscam) instructs the growth of axon terminals in Drosophila (Kim et al., 2013). The molecular mechanisms that underlie neural network assembly.This is a new frontier in developmental neuroscience and requires multidisciplinary approaches, including molecular, cellular, genetic, developmental, physiological, behavioral and computational approaches, which we have established in our lab. No pain, no gain: investigating how painful experiences change neural circuits and behaviorĬurrently, we are trying to discover the principles that govern the assembly of neural networks beyond those that regulate neuronal development (e.g., dendrite and axon development) and the connections between two groups of neurons (e.g., axon targeting and synapse development).Pathway-Specific Plasticity in a Developing Sensory Circuit (video abstract, Neuron, 2017).We also discovered a novel form of sensory-pathway-specific plasticity during the development of Drosophila larvae (Kaneko et al., 2017). Our lab reported the first neural-activity-dependent topographic map in Drosophila (Yang et al., 2013 Kaneko & Ye, 2015) and used this system to investigate the molecular mechanism underlying the assembly of neural circuits. All together now: Novel mechanism directs both dendritic and axonal growth in the same neuron, MedicalXpressīuilding on our strength in cell and developmental biology of neurons as well as Drosophila genetics, we studied the molecular, cell biological and developmental mechanisms that assembles neurons into functional neural circuits.Neuronal regeneration and the two-part design of nerve cells.Our lab also contributed to the understanding of the function, regulation and diversity of the Golgi apparatus in neurons and developed molecular tools for studying the Golgi complex in vivo in multi-cellular organisms. Using Drosophila systems, we identified molecular and cellular mechanisms that regulate dendrite and axon development differently. The distinct morphology of a neuron’s dendrites and axons is fundamental to the assembly of neural circuits. Dendrites and axons are the input and output compartments of a neuron, respectively.
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